SCORPIO version 2.0

Structure-Calorimetry Of Reported Protein Interactions Online

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For a full dataset and details of experiment click on the datum link or any thermodynamic datum in the table below.

Datum	Protein	Ligand	ΔG (kJ/mol)	ΔH (kJ/mol)	TΔS (kJ/mol)	KD (µM)	ΔCp (J/mol)
Link	Disabled Homolog 1 (native)	TKSMNFDNPVYRKT TKSMNFDNPVYRKT	-32.22	-40.17	-7.95	3.0
Link	Disabled Homolog 1 (H81A)	TKSMNFDNPVYRKT TKSMNFDNPVYRKT	-46.86	-48.53	-1.67	3.2
Link	Disabled Homolog 1 (H81Q)	TKSMNFDNPVYRKT TKSMNFDNPVYRKT	-33.05	-45.19	-12.13	1.6
Link	Disabled Homolog 1 (K45A)	TKSMNFDNPVYRKT TKSMNFDNPVYRKT	-32.22	-42.26	-10.04	2.3
Link	Disabled Homolog 1 (K45Q)	TKSMNFDNPVYRKT TKSMNFDNPVYRKT	-31.38	-33.89	-2.51	2.9
Link	Disabled Homolog 1 (K45E)	TKSMNFDNPVYRKT TKSMNFDNPVYRKT	-32.22	-44.35	-12.13	2.2
Link	Disabled Homolog 1 (K82A)	TKSMNFDNPVYRKT TKSMNFDNPVYRKT	-33.47	-46.02	-12.55	1.4
Link	Disabled Homolog 1 (K82Q)	TKSMNFDNPVYRKT TKSMNFDNPVYRKT	-33.05	-60.67	-27.61	1.7
Link	Disabled Homolog 1 (K45A/K82A)	TKSMNFDNPVYRKT TKSMNFDNPVYRKT	-31.38	-36.82	-5.44	3.0
Link	Disabled Homolog 1 (K45Q/K82Q)	TKSMNFDNPVYRKT TKSMNFDNPVYRKT	-31.8	-38.91	-7.11	2.7
Link	Disabled Homolog 1 (K45E/K82Q)	TKSMNFDNPVYRKT TKSMNFDNPVYRKT	-32.22	-42.68	-10.46	2.1
Link	Disabled Homolog 1 (native)	D-myo-inositol-1,4,5-triphosphate D-myo-inositol-1,4,5-triphosphate	-33.89	-80.33	-46.44	1.2
Link	Disabled Homolog 1 (H81A)	D-myo-inositol-1,4,5-triphosphate D-myo-inositol-1,4,5-triphosphate	-27.61	-46.86	-19.25	24.0
Link	Disabled Homolog 1 (H81Q)	D-myo-inositol-1,4,5-triphosphate D-myo-inositol-1,4,5-triphosphate	-26.78	-41.0	-14.23	18.0
Link	Disabled Homolog 1 (S114Y)	D-myo-inositol-1,4,5-triphosphate D-myo-inositol-1,4,5-triphosphate	-33.89	-102.09	-68.2	1.2
Link	Disabled Homolog 1 (F158V)	D-myo-inositol-1,4,5-triphosphate D-myo-inositol-1,4,5-triphosphate	-35.56	-75.73	-40.17	0.6

Disclaimer

This is an ongoing project and, although SCORPIO has been curated with great care, it may contain errors. If you spot an error please contact us. We take no responsibility for the data within SCORPIO, nor any responsibility for the consequences of using the data within SCORPIO. No contract, warranty or liability is implied by using the data within SCORPIO.

If you make use of SCORPIO please cite J. Mol. Biol. [2008] 384, 1002-1017
Tjelvar S. G. Olsson, Mark A. Williams, Will R. Pitt and John E. Ladbury