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For a full dataset and details of experiment click on the datum link or any thermodynamic datum in the table below.

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DatumProteinLigandΔG (kJ/mol)ΔH (kJ/mol)TΔS (kJ/mol)KD (µM)ΔCp (J/mol)
Link Trypsin N-alpha-(2-naphthylsulfonyl)-n-(3-amidino-l-phenylalaninyl)-d-pipecolinic acid-variant-1a N-alpha-(2-naphthylsulfonyl)-n-(3-amidino-l-phenylalaninyl)-d-pipecolinic acid-variant-1a diagram
N-alpha-(2-naphthylsulfonyl)-n-(3-amidino-l-phenylalaninyl)-d-pipecolinic acid-variant-1a 		-42.5 -27.1 15.4 0.04
Link Trypsin N-alpha-(2-naphthylsulfonyl)-n-(3-amidino-l-phenylalaninyl)-d-pipecolinic acid N-alpha-(2-naphthylsulfonyl)-n-(3-amidino-l-phenylalaninyl)-d-pipecolinic acid diagram
N-alpha-(2-naphthylsulfonyl)-n-(3-amidino-l-phenylalaninyl)-d-pipecolinic acid 		-36.4 -20.6 15.8 0.41 -2.59
Link Trypsin N-alpha-(2-naphthylsulfonyl)-n-(3-amidino-l-phenylalaninyl)-d-pipecolinic acid-variant-1bme N-alpha-(2-naphthylsulfonyl)-n-(3-amidino-l-phenylalaninyl)-d-pipecolinic acid-variant-1bme diagram
N-alpha-(2-naphthylsulfonyl)-n-(3-amidino-l-phenylalaninyl)-d-pipecolinic acid-variant-1bme 		-37.0 -16.9 20.6 0.32 -2.79
Link Trypsin N-alpha-(2-naphthylsulfonyl)-n(3-amidino-l-phenylalaninyl)isopipecolinic acid methyl ester-variant-1c N-alpha-(2-naphthylsulfonyl)-n(3-amidino-l-phenylalaninyl)isopipecolinic acid methyl ester-variant-1c diagram
N-alpha-(2-naphthylsulfonyl)-n(3-amidino-l-phenylalaninyl)isopipecolinic acid methyl ester-variant-1c 		-35.5 -26.8 8.7 0.6 -2.26
Link Trypsin N-alpha-(2-naphthylsulfonyl)-n(3-amidino-l-phenylalaninyl)isopipecolinic acid methyl ester N-alpha-(2-naphthylsulfonyl)-n(3-amidino-l-phenylalaninyl)isopipecolinic acid methyl ester diagram
N-alpha-(2-naphthylsulfonyl)-n(3-amidino-l-phenylalaninyl)isopipecolinic acid methyl ester 		-43.6 -39.6 4.0 0.02 -2.6
Link Trypsin N-alpha-(2-naphthylsulfonyl)-3-amidino-l-phenylalanine piperazide N-alpha-(2-naphthylsulfonyl)-3-amidino-l-phenylalanine piperazide diagram
N-alpha-(2-naphthylsulfonyl)-3-amidino-l-phenylalanine piperazide 		-40.8 -32.9 7.9 0.07 -2.2
Link Trypsin N-alpha-(2-naphthylsulfonyl)-n(3-amidino-l-phenylalaninyl)-4-acetyl-piperazine N-alpha-(2-naphthylsulfonyl)-n(3-amidino-l-phenylalaninyl)-4-acetyl-piperazine diagram
N-alpha-(2-naphthylsulfonyl)-n(3-amidino-l-phenylalaninyl)-4-acetyl-piperazine 		-42.6 -34.4 8.2 0.03 -2.56
Link Trypsin N-alpha-(2-naphthylsulfonyl)-3-amidino-l-phenylalanine piperazide-version-2 N-alpha-(2-naphthylsulfonyl)-3-amidino-l-phenylalanine piperazide-version-2 diagram
N-alpha-(2-naphthylsulfonyl)-3-amidino-l-phenylalanine piperazide-version-2 		-32.0 -4.4 27.6 2.5 -0.91
Link Trypsin [N-[n-(4-methoxy-2,3,6-trimethylphenylsulfonyl)-l-aspartyl]-d-(4-amidino-phenylalanyl)]-piperidine [N-[n-(4-methoxy-2,3,6-trimethylphenylsulfonyl)-l-aspartyl]-d-(4-amidino-phenylalanyl)]-piperidine diagram
[N-[n-(4-methoxy-2,3,6-trimethylphenylsulfonyl)-l-aspartyl]-d-(4-amidino-phenylalanyl)]-piperidine 		-38.3 -24.7 10.6 0.19 -1.2
Link Trypsin Benzamidine Benzamidine diagram
Benzamidine 		-26.9 -17.0 9.9 16.13 -0.4
Link Trypsin Benzamidine Benzamidine diagram
Benzamidine 		-26.6 -18.9 7.7 22.22 -0.4
Link Trypsin Benzamidine Benzamidine diagram
Benzamidine 		-26.7 -21.4 5.4 24.39 -0.4
Link Trypsin Benzamidine Benzamidine diagram
Benzamidine 		-26.7 -23.7 3.0 32.26 -0.4
Link Trypsin Benzamidine-para-amide Benzamidine-para-amide diagram
Benzamidine-para-amide 		-29.3 -24.1 5.2 5.95 -0.52
Link Trypsin Benzamidine-para-amide Benzamidine-para-amide diagram
Benzamidine-para-amide 		-29.1 -26.9 2.2 7.87 -0.52
Link Trypsin Benzamidine-para-amide Benzamidine-para-amide diagram
Benzamidine-para-amide 		-29.1 -30.2 -1.4 9.71 -0.52
Link Trypsin Benzamidine-para-amide Benzamidine-para-amide diagram
Benzamidine-para-amide 		-28.8 -33.0 -4.2 14.08 -0.52
Link Trypsin Benzamidine-para-methyl Benzamidine-para-methyl diagram
Benzamidine-para-methyl 		-27.5 -16.7 10.8 12.56 -0.42
Link Trypsin Benzamidine-para-methyl Benzamidine-para-methyl diagram
Benzamidine-para-methyl 		-27.6 -18.5 9.1 14.41 -0.42
Link Trypsin Benzamidine-para-methyl Benzamidine-para-methyl diagram
Benzamidine-para-methyl 		-27.5 -20.7 6.8 18.05 -0.42

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