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For a full dataset and details of experiment click on the datum link or any thermodynamic datum in the table below.

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DatumProteinLigandΔG (kJ/mol)ΔH (kJ/mol)TΔS (kJ/mol)KD (µM)ΔCp (J/mol)
Link Heat Shock Protein 90 N-terminal Domain, (E. coli expressed) Radicol Radicol diagram
Radicol 		-48.9 -22.8 26.09 0.0
Link Heat Shock Protein (Full length) Radicol Radicol diagram
Radicol 		-44.1 -33.7 10.41 0.02
Link Heat Shock Protein (Full length) Geldanamycin Geldanamycin diagram
Geldanamycin 		-33.8 -41.8 -7.99 1.22
Link c-Src SH2 Domain acetyl-pYYE-dipentylamine acetyl-pYYE-dipentylamine diagram
acetyl-pYYE-dipentylamine 		-37.24 -17.99 19.09 0.4
Link c-Src SH2 Domain Compound 2, charifson et al. Compound 2, charifson et al. diagram
Compound 2, charifson et al. 		-30.96 -16.32 14.6 4.2
Link c-Src SH2 Domain Compound 3, charifson et al. Compound 3, charifson et al. diagram
Compound 3, charifson et al. 		-33.89 -17.99 15.84 1.4
Link c-Src SH2 Domain acetyl-pYYE-methyl(cyclopentyl-propyl)amine acetyl-pYYE-methyl(cyclopentyl-propyl)amine diagram
acetyl-pYYE-methyl(cyclopentyl-propyl)amine 		-36.82 -29.71 7.11 0.4
Link c-Src SH2 Domain acetyl-pYYE-butylpiperidine acetyl-pYYE-butylpiperidine diagram
acetyl-pYYE-butylpiperidine 		-35.15 -22.59 12.47 1.0
Link c-Src SH2 Domain Compound 6, charifson et al. Compound 6, charifson et al. diagram
Compound 6, charifson et al. 		-31.8 -13.39 18.34 3.4
Link c-Src SH2 Domain Compound 7, charifson et al. Compound 7, charifson et al. diagram
Compound 7, charifson et al. 		-32.64 -19.25 13.35 2.3
Link c-Src SH2 Domain Compound 8, charifson et al. Compound 8, charifson et al. diagram
Compound 8, charifson et al. 		-42.26 -28.45 13.72 0.05
Link c-Src SH2 Domain Compound 9, charifson et al. Compound 9, charifson et al. diagram
Compound 9, charifson et al. 		-41.0 -25.94 14.97 0.09
Link c-Src SH2 Domain Compound 10, charifson et al. Compound 10, charifson et al. diagram
Compound 10, charifson et al. 		-36.82 -21.34 15.34 0.5
Link c-Src SH2 Domain Compound 11, charifson et al. Compound 11, charifson et al. diagram
Compound 11, charifson et al. 		-28.45 -28.45 11.7
Link c-Src SH2 Domain [acetyl]-[deoxy-difluoromethelene-phosphotyrosine]-E-[dipentylamine] [acetyl]-[deoxy-difluoromethelene-phosphotyrosine]-E-[dipentylamine] diagram
[acetyl]-[deoxy-difluoromethelene-phosphotyrosine]-E-[dipentylamine] 		-32.64 -21.34 11.23 2.4
Link c-Src SH2 Domain Compound 13, charifson et al. Compound 13, charifson et al. diagram
Compound 13, charifson et al. 		-38.07 -51.04 -12.85 0.2
Link c-Src SH2 Domain Compound 13, charifson et al. Compound 13, charifson et al. diagram
Compound 13, charifson et al. 		-38.07 -51.04 -12.85 0.2
Link c-Src SH2 Domain (C188A) Compound 13, charifson et al. Compound 13, charifson et al. diagram
Compound 13, charifson et al. 		-35.56 -7.53 27.82 0.6
Link HIV-1 Protease Indinavir Indinavir diagram
Indinavir 		-53.14 8.79 61.92 0.0
Link HIV-1 Protease Saquinavir Saquinavir diagram
Saquinavir 		-53.56 7.95 61.5 0.0

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